Search results for "Materials Science | Hot Paper"
showing 10 items of 1457 documents
Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy
2018
Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3 -AQCs)-developed by an ad hoc method-augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3 -AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3 -AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tiss…
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
2016
collaboration au projet H2020 European Cooperation in Science and Technology (COST) program European Network on Microvesicles and Exosomes in Health and Disease (ME-HAD); International audience; Recent research has demonstrated that all body fluids assessed contain substantial amounts of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes containing different membrane microdomains such as lipid rafts and caveolae. The most prominent representatives of these so-called extracellular vesicles (EVs) are nanosized exosomes (70-150 nm), which are derivatives of the endosomal system, and microvesicles (100-1000 nm), which are produced by outward budding…
OSIP1 is a self‐assembling DUF3129 protein required to protect fungal cells from toxins and stressors
2021
International audience; Secreted proteins are key players in fungal physiology and cell protection against external stressing agents and antifungals. Oak stress-induced protein 1 (OSIP1) is a fungal-specific protein with unknown function. By using Podospora anserina and Phanerochaete chrysosporium as models, we combined both in vivo functional approaches and biophysical characterization of OSIP1 recombinant protein. The P. anserina OSIP1(Delta) mutant showed an increased sensitivity to the antifungal caspofungin compared to the wild type. This correlated with the production of a weakened extracellular exopolysaccharide/protein matrix (ECM). Since the recombinant OSIP1 from P. chrysosporium …
Wpływ Brexitu na współpracę sądową w sprawach karnych w Unii Europejskiej
2020
Wystąpienie Zjednoczonego Królestwa z Unii Europejskiej stanowi jedno z głównych wyzwań dla dalszego funkcjonowania europejskiego obszaru wymiaru sprawiedliwości w sprawach karnych. W niniejszym artykule szczególna uwaga zostanie zwrócona na wybrane aspekty zapewnienia dalszej współpracy sądowej w sprawach karnych po Brexicie. Dotyczy to przede wszystkim możliwości dalszego udziału Zjednoczonego Królestwa w specyficznych organach wspomagających obrót prawny w ramach tej współpracy (tj. w ramach Eurojustu i Europolu) oraz stosowania instrumentów prawnych urzeczywistniających zasadę wzajemnego uznawania orzeczeń, ze szczególnym uwzględnieniem sztandarowego instrumentu prawnego, tj. europejski…
Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin
2017
Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellan-transfersomes obtained by an easy, scalable method. The vesicles were small in size (~107 nm) and monodispersed (P.I. ≤ 0.24), forming a viscous system (~24 mPa/s) as compared to transfersomes (~1.6 mPa/s), as confirmed by rheological studies. Gellan was anchored to the bilayer domains through cholesterol, and the polymer chains were distributed onto the outer surface of the bilayer, thus forming a core-shell structure, as suggested by SAXS analyses. The optimal carrier ability of core-shell gellan-transfersomes was established by the high deposition of baicalin in th…
Survey and Photogrammetric Restitution of Monumental Complexes: Issues and Solutions—The Case of the Manfredonic Castle of Mussomeli
2019
The latest results obtained through photogrammetric restitution enhanced by GNSS (Global Navigation Satellite System) RTK (Real-Time Kinematic) survey achieved increased levels of accuracy. These survey solutions are used to rapidly obtain a detailed model with an excellent level of accuracy (centimetric) with cheaper equipment. However, the contour conditions are not always favorable for obtaining the best results in a simple way. The work presented in this paper shows the survey and the photogrammetric restitution of the Manfredonic Castle of Mussomeli in Sicily, developed as a part of the PON NEPTIS European Project, aimed at the valorization of Cultural Heritage (CH). This case is a typ…
3D GPR Model in the Military District of San Giacomo Degli Spagnoli (Palermo)
2023
The georadar method was used to try to find some anthropic structures in a large square inside the Carabinieri barracks in the former military complex of San Giacomo degli Spagnoli in Palermo (Italy). These investigations are part of a broader context of a study of the entire area. The purpose of the investigations is to try to understand if under the ground there are the remains of an ancient horse passage that connected the Royal Palace of Palermo with the sea gate of the city. Furthermore, in the Middle Ages, on the site of the present square, there were most likely two churches, which no longer exist, as evidenced by numerous historical testimonies. One of the two, San Giacomo la Mazara…
Non-symmetrized Hyperspherical Harmonics Method for Non-equal Mass Three-Body Systems
2018
The non-symmetrized hyperspherical harmonics method for a three-body system, composed by two particles having equal masses, but different from the mass of the third particle, is reviewed and applied to the $^3$H, $^3$He nuclei and $^3_{\Lambda}$H hyper-nucleus, seen respectively as $nnp$, $ppn$ and $NN\Lambda$ three-body systems. The convergence of the method is first tested in order to estimate its accuracy. Then, the difference of binding energy between $^3$H and $^3$He due to the difference of the proton and the neutron masses is studied using several central spin-independent and spin-dependent potentials. Finally, the $^3_{\Lambda}$H hypernucleus binding energy is calculated using diffe…
Ionic liquid crystals based on viologen dimers: tuning the mesomorphism by varying the conformational freedom of the ionic layer
2016
ABSTRACTWe investigated the liquid crystal behaviour of newly synthesised bistriflimide salts of symmetric viologen dimers. A smectic A phase was observed for intermediate spacer lengths and for relatively long lateral alkyl chains. The systems were characterised by thermal analysis, polarised optical microscopy, X-ray scattering and solid-state NMR. An intermediate ordered smectic phase was also exhibited by the compounds (except for systems with very short lateral chains) consisting of molten layers of alkyl chains and partially ordered ionic layers. These results, relating to the mesomorphic behaviour of viologen salts, are qualitatively compared to those of the more common imidazolium s…
A Universal Length-Dependent Vibrational Mode in Graphene Nanoribbons
2019
Graphene nanoribbons (GNRs) have attracted considerable interest as their atomically tunable structure makes them promising candidates for future electronic devices. However, obtaining detailed information about the length of GNRs has been challenging and typically relies on low-temperature scanning tunneling microscopy. Such methods are ill-suited for practical device application and characterization. In contrast, Raman spectroscopy is a sensitive method for the characterization of GNRs, in particular for investigating their width and structure. Here, we report on a length-dependent, Raman active low-energy vibrational mode that is present in atomically precise, bottom-up synthesized armch…